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How effective is pharmacotherapy for overactive bladder?
Current first-line pharmacologic treatment options for primary overactive bladder and the direction of research on future agents yield an interesting mix of approaches to this troubling problem.
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Evaluating the painful shoulder
To assess a painful or weakened shoulder, employ a combination of range-of-motion and strength tests, history taking, and selective use of corticosteroid injection. The shoulder has a wide range of motion (ROM)—nearly 180 degrees in multiple planes—but it is a highly unstable joint. Its structure can be compared to that of a golf ball on a tee held in place by loose static stabilizers (the ligaments of the joint capsule).
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Tigecycline: A novel glycylcycline antiobiotic
Highly resistant strains of both gram-positive and gram-negative bacteria are becoming commonplace in both the inpatient and outpatient setting. Recently developed antimicrobials have targeted resistant gram-positive pathogens, but the problem of resistant gram-negative pathogens remains. Tigecycline is an injectable antimicrobial and the first in a new class of agents (the glycylcyclines) that possesses activity against key gram-positive and gram-negative bacterial pathogens.
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CASE & COMMENT: What to make of this apparent lung nodule?
A 79-year-old Hispanic man with a greater than 30-pack year smoking history presents to the pulmonary clinic for evaluation of a right upper lobe (RUL) lung nodule.
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